| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jameis Winston |
1. Jameis Winston, QB | CLE | W 29-24 vs. BAL | 27 | 41 | 334 | 3 | 0 | 2 | 1 | 115.3 |
| 2. Baker Mayfield, QB | TB | L 31-26 vs. ATL | 37 | 50 | 330 | 3 | 2 | 0 | 0 | 94.6 | |
| 3. Jayden Daniels, QB | WSH | W 18-15 vs. CHI | 21 | 38 | 326 | 1 | 0 | 2 | 0 | 92.7 | |
| 4. Trevor Lawrence, QB | JAX | L 30-27 vs. GB | 21 | 32 | 308 | 2 | 1 | 1 | 1 | 104.7 | |
| 5. Kyler Murray, QB | ARI | W 28-27 at MIA | 26 | 36 | 307 | 2 | 0 | 0 | 0 | 116.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
D'Andre Swift |
1. D'Andre Swift, RB | CHI | L 18-15 at WSH | 18 | 129 | 7.2 | 1 | 56 | 0 | |
| 2. Jahmyr Gibbs, RB | DET | W 52-14 vs. TEN | 11 | 127 | 11.5 | 1 | 70 | 0 | ||
| 3. Josh Jacobs, RB | GB | W 30-27 at JAX | 25 | 127 | 5.1 | 2 | 38 | 0 | ||
| 4. James Cook, RB | BUF | W 31-10 at SEA | 17 | 111 | 6.5 | 2 | 18 | 0 | ||
| 5. Saquon Barkley, RB | PHI | W 37-17 at CIN | 22 | 108 | 4.9 | 0 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Calvin Ridley |
1. Calvin Ridley, WR | TEN | L 52-14 at DET | 10 | 143 | 14.3 | 0 | 47 | 1 | |
| 2. George Kittle, TE | SF | vs. DAL | 6 | 128 | 21.3 | 1 | 43 | 0 | ||
| 3. Terry McLaurin, WR | WSH | W 18-15 vs. CHI | 5 | 125 | 25.0 | 0 | 61 | 0 | ||
| 4. Trey McBride, TE | ARI | W 28-27 at MIA | 9 | 124 | 13.8 | 0 | 37 | 0 | ||
| 5. Justin Jefferson, WR | MIN | L 30-20 at LAR | 8 | 115 | 14.4 | 0 | 27 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Ivan Pace Jr. |
1. Ivan Pace Jr., LB | MIN | L 30-20 at LAR | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 |
| 2. Harrison Smith, S | MIN | L 30-20 at LAR | 6 | 2 | 8 | 0.0 | 0 | 0 | 0 | |
| 3. Andrew Van Ginkel, LB | MIN | L 30-20 at LAR | 4 | 3 | 7 | 0.0 | 0 | 0 | 0 | |
| 4. Camryn Bynum, S | MIN | L 30-20 at LAR | 3 | 4 | 7 | 0.0 | 0 | 0 | 0 | |
| 5. Josh Metellus, S | MIN | L 30-20 at LAR | 3 | 4 | 7 | 0.0 | 0 | 0 | 0 | |